The Red Devils will be licking their wounds following a damaging 3-0 defeat against Sevilla on Thursday night, which knocked them out of the Europa League at the quarter-final stage.
In-form Brighton are arguably favourites for the tie but will be wary they will be coming up against a wounded animal looking to make amends.
The Old Trafford club will definitely be without key defenders Lisandro Martinez and Raphael Varane, who both suffered injuries in the first-leg against Sevilla.
Skipper Harry Maguire also misses out through suspension. That means Bruno Fernandes – who was suspended for the trip to Spain – is expected to start and take back the captain’s armband.
Marcus Rashford, who came off the bench in the second-half at the Ramon Sanchez-Pizjuan Stadium, is expected to start after making a quick recovery from a groin injury.
Here’s is how we think Erik Ten Hag’s full line-up will look:
The Old Trafford club will definitely be without key defenders Lisandro Martinez and Raphael Varane, who both suffered injuries in the first-leg against Sevilla.